Contemporary global distribution of ABO polymorphism

Abstract

ABO is considered to be one of the most sophisticated and therapeutically useful blood group systems in transfusion and forensic medicine. Many of the SNP variations are discovered in the ABO gene and are available in publicly accessible databases, like GenBank and Ensemble. Since the ABO gene is approximately 25 kbp long, noncoding sequences constitute the majority of the locus. Out of 1065 nucleotides of the coding region, SNP variations of more than 500 positions are already identified. Furthermore, as more genomes are sequenced, the number of ABO alleles is increasing rapidly. Following a brief overview, we discussed the prevalence of ABO genotypes in various populations around the world. The data was compiled from studies published in peer-reviewed journals between 1997 and 2021. Although, the data is insufficient still we have provided the prevalence of ABO blood genotypes in various populations throughout the world. As a result, we presume that this data will improve our understanding of ABO blood types and their role in numerous areas of population genetics.