Contemporary aspects of the study of the pharmacodynamics of drugs obtained on the base of organic raw materials

Abstract

The intensive development of animal husbandry and the current international requirements for obtaining ecologically safe, organic foods of agricultural production determine the need to find new means of animal health protection using natural raw materials. In this review, we aim to reveal the directions for obtaining such drugs that can potentially be used in veterinary medicine, as well as the modern principles of studying their pharmacodynamics. The available literature for the past ten years obtained from the electronic databases, such as PubMed, Web of Science, Springer, and Google Scholar has been analyzed. Methodical approaches to obtaining preparations from propolis, various plant raw materials, silkworm pupae, complex products based on metal nanoparticles and organic components have been considered. Along with this, the results of studying the pharmacokinetics of the above mentioned drugs in vitro and in vivo, as well as modern methods of studying their biological effects, including the molecular level using RT-PCR and western blotting, have been highlighted. The issue of studying pharmacodynamics in the context of preclinical studies of biological and pharmacological drugs, taking into account the principles of interspecies extrapolation of dose and its scaling, has also been raised. The presented material can provide new ideas for modern ecological means for animal protection development and determination of their pharmacodynamics characteristics on biological models of different levels