Abstract
BackgroundType 2 diabetes (T2D) is a known risk factor for cardiovascular disease (CVD), and CVD is a major cause of mortality in patients with T2D. The CAPTURE study investigated the contemporary (2019) prevalence of established CVD in adults with T2D around the world. We report the findings from Brazil.MethodsThe multinational, non-interventional, cross-sectional CAPTURE study was conducted across 13 countries from five continents. The current manuscript explores data for the CAPTURE study sample in Brazil. Standardized demographic and clinical data were collected from adults with T2D aged ≥ 18 years attending a single routine healthcare visit in primary or specialized care between December 2018 and September 2019. Data were analyzed descriptively.ResultsData from 912 adults with T2D were collected in the CAPTURE study in Brazil, with 822 patients from primary care and 90 patients from specialized care. Median (interquartile range [IQR]) patient characteristics were as follows: age 64 years (57; 71), diabetes duration 11 years (6; 19), glycated hemoglobin 7.7% (6.7; 9.1), and body mass index 29.5 kg/m2 (26.4; 33.5); 59% were female. The CVD prevalence and atherosclerotic CVD prevalence in the Brazil sample were 43.9% (95% confidence interval [CI] 40.9; 46.8) and 37.6% (95% CI 34.7; 40.5), respectively. The majority of patients with CVD had atherosclerotic CVD (85.8%). For the specific CVD subtypes, coronary heart disease prevalence was 27.9% (95% CI 25.2; 30.5), heart failure was 12.4% (95% CI 10.4; 14.4), cerebrovascular disease was 8.7% (95% CI 6.8; 10.5), and carotid artery disease was 3.4% (95% CI 2.3; 4.5). Glucagon-like peptide-1 receptor agonists and/or sodium-glucose co-transporter-2 inhibitors with proven cardiovascular benefit were prescribed to 15.5% of patients with CVD, compared with 18.4% of patients without CVD.ConclusionsCAPTURE was the first multinational, standardized study to provide contemporary data on CVD prevalence in adults with T2D in Brazil, and it demonstrated that almost one in two adults with T2D had established CVD. Except for carotid artery disease, the prevalence of all CVD subtypes in adults with T2D in Brazil appeared higher than the global CAPTURE prevalence.Trial registration NCT03786406, NCT03811288
Highlights
Type 2 diabetes (T2D) is a known risk factor for cardiovascular disease (CVD), and CVD is a major cause of mortality in patients with T2D
Study population Data from 912 patients with T2D were collected across 21 sites in the CAPTURE study in Brazil, with 822 patients attending primary care sites and 90 attending specialist care sites
Analysis of the data for key demographic or clinical characteristics of the overall CAPTURE Brazil sample showed that 59.0% of the population were female; median data for age were 64.0 years (57.0; 71.0), with diabetes duration 11.0 years (6.0; 19.0), glycated hemoglobin (HbA1c) 7.7% (6.7; 9.1), and body mass index (BMI) 29.5 kg/m2 (26.4; 33.5)
Summary
Type 2 diabetes (T2D) is a known risk factor for cardiovascular disease (CVD), and CVD is a major cause of mortality in patients with T2D. The International Diabetes Federation (IDF) has estimated a national prevalence of diabetes of 11.4% among adults aged 20 to 79 years. This represents an estimated 16.8 million people currently living with diabetes, with the figure predicted to rise to 26 million by 2045. More recent data from the Risk and Protection Factors Surveillance System for Chronic Diseases by Telephone Survey (Vigitel) study in 2019 showed that the prevalence of self-reported diabetes in adults was 7.4%, indicating an increase compared with 2011, which was 5.6% [5]
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