Abstract
The natural occurrence of fumonisin B 1 (FB 1 ) in Indian maize and its impact on the viability and phagocytosis of chicken peritoneal macrophages in vitro were investigated. FB 1 was found to be present at the levels of 300-366 ppm in Fusarium moniliforme-infected maize grains. The infected kernels in a population of 100 ears showed normal (Gaussian) frequency distribution. FB 1 , extracted from the contaminated kernels, reduced the viability and phagocytic activity of macrophages. These findings imply that FB 1 exposure may become a potential problem in India and may lead to decreased immune responses with consequent susceptibility of a host to infection
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