Contact-lens-related corneal ulcer caused by klebsiella pneumoniae

Abstract

The use of contact lenses (CLs) has been widely associated with corneal alterations that range in symptomatology and severity. Lesions may vary from small peripheral sterile infiltrates to infectious central ulcers with sight-threatening potential.1 Contact lens wear has been described as the most important predisposing factor to microbial keratitis worldwide.2 Infections are more frequent in soft-lens users, and the risk with gas-permeable rigid lenses is estimated to be one-third of that with daily-wear soft lenses. Extended wear is also associated with a higher risk of microbial keratitis.3 Bacterial keratitis is most commonly caused by aggressive gram-negative Pseudomonas spp.; Klebsiella spp. is rarely the causative agent of keratitis due to contact lens wear.4 We present a case of contact-lens-related bacterial keratitis caused by Klebsiella pneumoniae. Case Presentation A 19-year-old man presented to our service complaining of pain and hyperemia of two days' duration in the right eye. He had been a regular contact lens wearer for two years. The patient used multipurpose solutions for cleaning, disinfecting, and storing daily-wear soft contact lenses. Recently, the lenses had been worn for extended periods of time. His visual acuity was at the level of finger counting. Ophthalmologic examination revealed central corneal keratitis in his right eye (Figure 1) Figure 1 Central corneal keratitis in the right eye. Samples from conjunctival swabbing and corneal scraping, the contact lens, the cleaning solution, and the case were all submitted for microbiological analysis. Gram staining revealed gram-negative microorganisms in the corneal scraping and in the contact lens cleaning solution. Cultures on appropriate media were positive for Klebsiella pneumoniae in these specimens. The organism was susceptible to aminoglycosides and to fourth-generation fluoroquinolones. The patient was treated topically with moxifloxacin (0.5%) and tobramycin (15 mg/ml) drops every hour and cyclopentolate 2% three times daily in the right eye. N-acetylcysteine eye drops were administered four times per day. After clinical improvement (four days later), topical corticosteroid drops were prescribed. The infection resolved, but residual central stromal opacification remained (Figure 2). The patient achieved a final visual acuity of 20/100 in the right eye. Figure 2 The infection resolved, but residual central stromal opacification remained in the right eye. DISCUSSION Contact-lens–related corneal infections continue to present a major challenge to ophthalmologists. With the continuous improvement in lens materials and design, as well as in disinfecting and storing solutions, contact lens use is on the rise. Currently, patients can use a single solution to rinse, disinfect, and store their lenses without the need for rubbing or enzymatic cleaning.5 The patient described herein used multipurpose solution for cleaning, disinfecting, and storing daily-wear soft contact lenses. The extended wear reported may have caused this case of microbial keratitis.3 Gram-negative bacteria include opportunistic enterobac­teria (such as Serratia spp. and Klebsiella spp.) that can survive in contact lens fluid and on plastic surfaces, which explains their increased numbers in contact-lens-induced corneal infections.6 Contact-lens-related keratitis may vary from small peripheral sterile infiltrates to infectious central ulcers with sight-threatening potential, as in our case.7 Overnight wear and, to a lesser extent, improper lens care are known to be major risk factors for corneal infection.8 Lam et al. reported a five-fold increase in the risk of microbial keratitis among patients who wear their contact lenses overnight.3 As reported by several authors, contact-lens-induced keratitis is mainly caused by gram-negative micro­organisms.4,8 However, Klebsiella spp. are not a common cause of bacterial keratitis. One study that investigated the causes of microbial keratitis showed that 3.2% of microbial keratitis cases were due to contact lens use. The same study showed that in 2.2% of these keratitis patients, Enterobacter spp. was the causative agent.9 In another study, 33 patients with contact-lens-related keratitis were followed. Klebsiella spp. were observed in the cultures of only two patients.10 N-acetylcysteine is a potential candidate for use as an inhibitor of Klebsiella biofilm formation. Therefore, we added N-acetylcysteine eye drops to the patient's treatment regimen.11 The majority of keratitis was caused by soft contact lens wear. One-fifth of these comparatively young patients displayed corneal scars.12 This case highlights the need for clinicians to be aware that Klebsiella spp. can induce contact-lens-related corneal ulcers.