Abstract
Color vision deficiency (color blindness) is an inherited genetic ocular disorder. While no cure for this disorder currently exists, several methods can be used to increase the color perception of those affected. One such method is the use of color filtering glasses which are based on Bragg filters. While these glasses are effective, they are high cost, bulky, and incompatible with other vision correction eyeglasses. In this work, a rhodamine derivative is incorporated in commercial contact lenses to filter out the specific wavelength bands (≈545–575 nm) to correct color vision blindness. The biocompatibility assessment of the dyed contact lenses in human corneal fibroblasts and human corneal epithelial cells shows no toxicity and cell viability remains at 99% after 72 h. This study demonstrates the potential of the dyed contact lenses in wavelength filtering and color vision deficiency management.
Highlights
Color vision deficiency is an inherited genetic ocular color can be recreated by combining blue, disorder
The dip method was found to provide improved immobilization of the dye when used on poly(2-hydroxyethyl methacrylate) (pHEMA) contact lenses
Low cost of the dye, and the ease of the production process, these dyed contact lenses can be promising for Color vision deficiency (CVD) management
Summary
The stabilities of the dip and drop methods (explained in Experimental Section) were compared (Figure 2). As over 24 h, the transmission dip decreased only 7% for the dip-coated lens compared to 42% for the drop-cast lens (Figure 2b,c) This may be attributed to the contact lens not fully absorbing the dye—most of the dye dried out on the surface without diffusing into the lens (Section S2, Supporting Information). Compared to the soft contact lens, the pHEMA contact lens showed lower ability to absorb the dye Due to this poor absorption capability, its transmission (86%) dip was smaller than that of the soft contacts (26%) (Figure 2d). Dyes are capable of absorbing narrow ranges of wavelength that can be controlled by altering their chemical structure.[25] While both dyes and Bragg mirrors can be synthesized to be highly selective light filters, dye processing does not require complex preparation methods This method could potentially be used for both glass spectacles and contact lenses at low cost. Encapsulation is an alternate stabilizing method to immobilize the dye
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