Abstract
Contact inhibition against senescence.
Highlights
Cellular senescence is a form of irreversible growth arrest historically associated with the exhaustion of replicative potential of in vitro cultured cells
The reversible contact inhibition was accompanied by suppression of the activating phosphorylation of AKT and the phosphorylation of ribosomal S6 protein in normal cell lines derived from multiple origins, including retinal pigment epithelial (RPE) cells, human WI38t fibroblasts, normal human bladder cells (NBCs) and rat intestinal epithelial IEC18 cells
These findings indicate that suppression of the AKT/mammalian target of rapamycin (mTOR) pathway is a general phenomenon associated with contact inhibition in normal cells
Summary
Cellular senescence is a form of irreversible growth arrest historically associated with the exhaustion of replicative potential of in vitro cultured cells. Another type of quiescence is contact inhibition, in which cells become growth arrested when they contact each other at high density. It had been a mystery what signaling pathways differentiate irreversible senescence from reversible quiescence induced by growth factor deprivation or contact inhibition.
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