Abstract
Background: Dichlofluanide is a common fungicide in glazing paints, varnishes, and paints. Objective: The objective of this study was to describe 5 patients with allergic contact dermatitis from dichlofluanide and to examine the sensitizing capacity of dichlofluanide in a predictive assay. Methods: Patch testing in humans and sensitization studies in animals were performed with the guinea pig maximization test. Results: Four of the patients were primarily sensitized to dichlofluanide, whereas 1 patient had probably been primarily sensitized to tolylfluanide when exposed to this pesticide. Sensitization studies in guinea pigs showed dichlofluanide to be a strong sensitizer. Conclusion: Dichlofluanide can cause allergic contact dematitis in humans and is a strong sensitizer in guinea pigs.
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