Contact Activity in Cerebrovascular Disorders

Abstract

An Association of contact factor with arteriosclerotic disorders relating to coagulation, fibrinolysis and kinin reíase was investigated by assessment in plasma of cerebrovascular patients. Contact activity was determined in plasma of 89 cerebrovascular patients and of 42 healthy controls following Waaler’s method. Patients’ activity was significantly higher than that of controls. The activity in patients with normal ECG findings was significantly higher compared with abnormal ECG cases. In patients with normal ECG findings, the activity of hypertensives was higher than that of normotensives, in patients elapsed over 4 months after their admisson it was higher than that in one month, in patients with good marks in the test of activities of daily livings (ADL-T) it was higher than that with poor marks. In normotensive patients with abnormal ECG findings, the activity was inversely proportional to serum cholesterol and 3-lipoprotein levels. The high activity in patients with normal ECG findings and few arteriosclerotic changes in contrast to patients with abnormal findings, and the inverse correlations between the activity and two lipids are unreasonable considering only the participation of the coagulation system triggered by contact factor. Therefore, the high activity must be regared as the result of participation of the fibrinolytic system activated by this factor. Although the high activity in patients with normal ECG findings and hypertension may be regarded as the protective effect of the fibrinolytic system to developement of arteriosclerosis induced by hypertension, and may be appreciated as the direct effect of kinin release by this factor in hypertension.