Abstract
BackgroundDiabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two complications that may develop in diabetic patients if hyperglycemia, insulin resistance, and weight gain are not controlled. This study investigated the effects of melatonin supplementation on some cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus (T2DM).Materials and methodsIn this double-blind, randomized, placebo-controlled trial, 50 T2DM patients were randomly allocated to intervention and control groups which received two tablets of either melatonin or placebo (250 mg) once a day for 8 weeks. Systolic blood pressure (SBP), mean arterial pressure (MAP), pulse pressure (PP), the atherogenic index of plasma (AIP), weight, body mass index (BMI), waist and hip circumference (WC, HC), a body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), lipid accumulation product (LAP), conicity index, and waist-to-height ratio (WHtR) were evaluated in all the patients pre- and post-intervention.ResultsMelatonin supplementation for 8 weeks significantly decreased the mean levels of SBP, MAP, PP, weight, BMI, WC, HC, BAI, AVI, conicity index, and WHtR post-intervention (p < 0.05). Also, the median changes of SBP, MAP, PP, weight, BMI, WC, HC BAI, AVI, and conicity index were significantly lower in the intervention group compared with the control group (p < 0.05). A significant increase (p < 0.001) was observed in the mean levels of ABSI in the intervention group. The median changes of ABSI were significantly greater in the intervention group compared with the control group (p < 0.001).ConclusionsConsumption of melatonin supplement may be effective in controlling arterial pressure including SBP, MAP, and PP and anthropometric indices (as predictors of obesity) in T2DM patients.Trial registrationIranian Registry of Clinical Trials IRCT20190303042905N1. Registered on 17 May 2019.
Highlights
Diabetes mellitus is a common chronic disease
Melatonin supplementation for 8 weeks significantly decreased the mean levels of Systolic blood pressure (SBP), mean arterial pressure (MAP), pulse pressure (PP), weight, body mass index (BMI), WC, HC, body adiposity index (BAI), abdominal volume index (AVI), conicity index, and waist-to-height ratio (WHtR) post-intervention (p < 0.05)
The median changes of SBP, MAP, PP, weight, BMI, WC, HC BAI, AVI, and conicity index were significantly lower in the intervention group compared with the control group (p < 0.05)
Summary
Dyslipidemia and hypertension are two complications that may develop in diabetic patients if hyperglycemia, insulin resistance, and weight gain are not controlled. This study investigated the effects of melatonin supplementation on some cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus (T2DM). There are clusters of metabolic abnormalities in type 2 diabetes mellitus (T2DM), including hyperglycemia, insulin resistance, and inflammation, which increase the risk of cardiovascular disease (CVD) [1]. T2DM patients are at a higher risk of developing dyslipidemia which is an important risk factor for coronary artery disease (CAD) [4]. Studies indicate that there is a positive correlation between AIP and the risk of CVD [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
