Abstract
We study the effect of noise on p53 regulatory network, the core of a cell's modulator for switching between survival and apoptosis. We find that the fluctuations, originating from stochastic expression of p53-responsive genes, introduce marked advantages for the system to sense external stimuli and sustain the function of switches. The coherence between a stimulus and the system's response undergoes a maximum with the raise of noise level, indicating the occurrence of stochastic resonance. The biological significance of our results is discussed.
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