Abstract
As(III) is a toxic heavy metal which causes serious health problems. Therefore, the development of highly sensitive sensors for As(III) detection is of great significance. Herein, a turn-on luminescence resonance energy transfer (LRET) method based on luminous nanorods was designed for As(III) detection. Biotin-labelled As(III) aptamers were tagged to avidin functionalized luminous nanorods as energy donors, while graphene oxide (GO) acted as the energy acceptor. The adsorption of single-stranded DNA on graphene oxide resulted in the efficient quenching of the luminescence of the nanorods through the LRET process. In the presence of As(III), aptamers bonded to As(III) preferentially and resulted in the formation of aptamer-As(III) complexes. The aptamer-As(III) complexes were rubbed off from the GO surface due to their conformational change, which led to the recovery of the luminescence of the nanorods. A good linear relationship between the luminescence intensity and concentration of As(III) was obtained in the range from 1 to 50 ng·mL−1, with a detection limit of 0.5 ng·mL−1. Furthermore, the developed sensors showed good specificity towards As(III) and proved capable of detecting As(III) in the environment and food samples. The proposed time-resolved sensors provide a promising sensing strategy for the rapid and sensitive detection of As(III).
Highlights
As(III) is a toxic heavy metal, which is about 60 times more toxic than other forms of arsenic [1]
Inorganic arsenic is mostly found in environmental water: the World Health Organization (WHO) has set the upper limit for the content of As(III) in environmental water to 10 ppb [3]
Organic arsenic is the main form of arsenic in aquatic products [4], studies have shown that the content of inorganic arsenic in shellfish living in arsenic-contaminated waters has increased significantly, and the toxicological problems caused by inorganic arsenic still cannot be ignored [5,6]
Summary
As(III) is a toxic heavy metal, which is about 60 times more toxic than other forms of arsenic [1]. The detection principle of As(III) by the time-resolved fluorescent probe via a luminescence resonance energy transfer (LRET). The detection principle of As(III) by the time-resolved fluorescent probe via a luminescence 2. The sizes of the prepared Zn2GeO4:Mn fluorescent materials were all at the nanometer level, and a single particle exhibited a regular rod-like shape. HTehegrgereenenememisissisoionnaat t553333nnmmiissaattttrriibbuutteedd ttoo tthhee eessccaappeedd eelleeccttrroonnss mmoovveedd bbyy tthheeeexxcciitteeddeenneerrggyylleevveellooffMMnn22++,, rreessuullttiinngg iinn tthhee rreeccoommbbiinnaattiioonn ooff tthhee eelleeccttrroonnss wwiitthh hhoolleess tthhaatt aarree ggeenneerraatteedd bbyy tthhee nnaannoorrooddss ZZGGOO::MMnn uunnddeerr UUVV eexxcciittaattiioonn [[2200]]. S:0i.m5%ilaMrlny-,NthHe2.inStimenislaitrylyo,fththeeinUteVn-svitisy aobfstohrepUtioVn-vpiseaakbsaotr2p6t0ionnmpefaokr tahte26b0iontimn-flaobr ethlleedbiaoptitna-mlaebreslluepdearpntaatmanetrwsuaps e0r.n90a6ta, natnwd aits d0e.9c0r6e,aasendd tiot 0d.e4c6r5eaasfetedr ttohe0i.n46te5raacfttieornthbeetiwneteernacbtiiootninbaentwdeaevnidbiniot(iFnigaunrde 4adv)i.dTinhe(Fsiiggunriefic4adn)t. dTehceresaisgenioffictahnet adbescorrepastieonofptehaekaibnstoernpstiitoyninpdeiackatienstethnasittythienbdiiocatitneysltahteadt tahpetabmioetirnwylaastesducacpetsasmfuelrlywaatstascuhcecdestsofuthlley sauttrafachceedoftoZGthOe :s0u.5r%faMceno-favZiGdiOn:.0.5%Mn-avidin
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