Abstract
AbstractThe aldol reaction of the substituted cyclopentane carbaldehydes 1 with heptan‐2‐one was demonstrated to offer an effective alternative to the carbonyl olefinations generally used for the build‐up of the (E)‐3‐oxooct‐1‐enyl side chain of 11‐deoxyprostaglandins. In this case dimethyl 2‐oxoheptylphosphonate can be substituted advantageously by the cheaper heptan‐2‐one as side chain precursor.
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