Construction of six complexes from 2-(2-pyridyl)benzothiazole and polycarboxylic acids: Synthesis, crystal structures and DNA-binding properties

Abstract

Abstract Six complexes including [Cd (bpt)(odc)2] (1), [Ni(bpt)(odc)2] (2), [Zn (bpt)(odc)2] (3), [Zn (bpt)(1,4-ndc)2(H2O)] (4), [Cd (bpt)(1,4-ndc)2] (5), [Cd (bpt)(Pta)2(H2O)2] (6), {bpt = 2-(2 pyridyl)benzothiazole, H2odc = 4,4′-oxybisbenzoic acid, 1,4-H2ndc = naphthalene-1,4-dicarboxylic acid, Pta = terephthalic acid}, have been determined by single-crystal X-ray diffraction analysis, which shows that complexes 1–3 belong to monoclinic system with space group P21/n, complex 4 and complex 6 belong to triclinic system with space group P-1, complex 5 belongs to monoclinic system with space group P21/c. TD-DFT calculations for the complexes 3 was performed to explain the structures and electronic spectral properties. UV spectroscopy, fluorescence spectroscopy and viscosity were used to characterize the interaction of the CT-DNA complexes. The results indicate that complexes 1–6 have strong interaction with CT-DNA binding. All complexes exhibit an electrostatic or groove mode of binding with DNA. Furthermore, they also present that all complexes have strong ability to interact with DNA. It can effectively destroy the DNA acting on cancer cells. Therefore, we hope to provide a theoretical and scientific basis for the development of anti-cancer drugs.