Abstract
Polymeric nanomaterials made from amphiphilic block copolymers are increasingly used in the treatment of tumor tissues. In this work, we firstly synthesized the amphiphilic block copolymer PBnMA-b-P(BAPMA-co-PEGMA) via reversible addition-fragmentation chain transfer (RAFT) polymerization using benzyl methacrylate (BnMA), poly (ethylene glycol) methyl ether methacrylate (PEGMA), and 3-((tert-butoxycarbonyl)amino)propyl methacrylate (BAPMA) as the monomers. Subsequently, PBnMA-b-P(APMA-co-PEGMA)@NIR 800 with photothermal conversion property was obtained by deprotection of the tert-butoxycarbonyl (BOC) groups of PBAPMA chains with trifluoroacetic acid (TFA) and post-modification with carboxyl functionalized ketocyanine dye (NIR 800), and it could self-assemble into micelles in CH3OH/water mixed solvent. The NIR photothermal conversion property of the post-modified micelles were investigated. Under irradiation with NIR light (λmax = 810 nm, 0.028 W/cm2) for 1 h, the temperature of the modified micelles aqueous solution increased to 53 °C from 20 °C, which showed the excellent NIR photothermal conversion property.
Highlights
As a research hotspot in recent years, the application of nanomaterials in biomedicine [1,2,3], information transmission [4,5,6], and other fields is becoming more and more extensive
We successfully synthesized the functional micelles with excellent NIR photothermal amphiphilic block copolymer PBnMA-b-P(BAPMA-co-PEGMA)@NIR 800, which was synthesized conversion performance
The micelles were obtained from the self-assembly of post-modified through reversible addition-fragmentation chain transfer (RAFT) polymerization, deprotection, and post-modification with ketocyanine dye NIR 800
Summary
As a research hotspot in recent years, the application of nanomaterials in biomedicine [1,2,3], information transmission [4,5,6], and other fields is becoming more and more extensive. Poly (ethylene glycol) methyl ether methacrylate (PEGMA) is a highly hydrophilic material with excellent biocompatibility and is usually used as hydrophilic monomer in the design of amphiphilic block copolymers [10,11,12]. It is suitable for a variety of polymerization methods, such as RAFT polymerization [13,14,15], atom transfer radical polymerization (ATRP) [16,17,18], etc. During the self-assembly of PEGMA based amphiphilic block copolymer, the PEG chains of the micelle hydrophilic shell are fully stretched in water to prevent entanglement and aggregation between the chains, and the stability of micelles is greatly increased.
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