Abstract
The reactions of N‐sulfonylhydrazones derived from cyclic ketones with γ‐azidopropylboronic acid and 2‐(azidomethyl)phenylboronic acid give rise to spirocyclic pyrrolidines and spiroisoindolines, respectively. The reactions proceed without the need of any transition‐metal catalyst through a domino process that comprises the formation of a Csp3‐C and a Csp3‐N bond of the former hydrazonic carbon. The scope of the reaction has been explored by the preparation of over 50 examples of NH‐unprotected spirocyclic derivatives. Importantly, this methodology could be applied for the preparation of alkaloid steroids from steroid N‐tosylhydrazones.
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