Abstract

Construction of New Coated Carbon Electrodes for Determination of Sildenafil Citrate Drug

Highlights

  • Viagra (Sildenafil citrate SILC) is a white to off-white crystalline powder of molecular weight of 666.7 g/mole and its formula is C28H38N6O11S

  • The studies show that Viagra successfully treats erectile dysfunction in men with co morbidities such as hypertension [4], diabetes [5], and depression [6].The side effects of SILC have been reported such as headache, congestion, flushing and dyspepsia [7,8,9]

  • Elemental analysis and FT-IR spectroscopy was carried out to confirm the composition of the ion-pair (SILC-phosphotungstic acid (PTA)) and (SILC-PMA)

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Summary

Introduction

Viagra (Sildenafil citrate SILC) is a white to off-white crystalline powder of molecular weight of 666.7 g/mole and its formula is C28H38N6O11S. The studies show that Viagra successfully treats erectile dysfunction in men with co morbidities such as hypertension [4], diabetes [5], and depression [6].The side effects of SILC have been reported such as headache, congestion, flushing and dyspepsia [7,8,9]. The present work describes preparation, characterization and application of coated carbon electrodes for determination of Viagra in pure and pharmaceutical preparations. Performance characteristics of (SILC-PMA) and (SILC-PTA) coated carbon electrodes reveal low detection limit, high sensitivity, good selectivity, fast response time, very long life time and application with accurate determination of Viagra in pharmaceutical preparations

Reagents and Materials
Sample Preparation
Stock Solutions of Interfering Ions
Preparation of Ion-Pairs:
Preparation of Coated Carbon Sensor
Results and Discussion
Calibration Plot of the Fabricated Electrodes and Limit of Detection
Effect of pH
Effect of Temperature
Selectivity of the Studied Sensors
Life time and response time
Precision and Accuracy
Analytical Applications
Conclusion
Full Text
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