Construction of Multiplex Muscle Network for Precision Pinch Force Control.

Abstract

Muscle synergy is a fundamental mechanism of motor control. Despite a number of studies focusing on muscle synergy during power grip and pinch at high-level force, relatively less is known about the functional interactions between muscles within low-level force production during precision pinch. Traditional analytical tools such as nonnegative matrix factorization or principal component analysis have limitations in processing nonlinear dynamic electromyographic signals and have confined sensitivity particularly for the low-level force production. In this study, we developed a novel method - multiplex muscle networks, to investigate the dynamical coordination of muscle activities at low-level force production during precision pinch. The multiplex muscle network was constructed based on multiplex limited penetrable horizontal visibility graph (MLPHVG). Seven forearm and hand muscles, including brachioradialis (BR), flexor carpi ulnaris (FCU), flexor carpi radialis (FCR), flexor digitorum superficialis (FDS), extensor digitorum communis (EDC), abductor pollicis brevis (APB) and first dorsal interosseous (FDI), were examined using surface electromyography (sEMG). Eight healthy subjects were instructed to perform a visuomotor force tracking task by producing higher (10% MVC) and lower (1% MVC) precision pinch. Interlayer mutual information I, average edge overlap ω weighted clustering coefficient CW, weighted characteristic path length LW were selected as network metrics. We assessed the undirected weighted network generated from multiplex muscle network after taking the I between paired muscle network layers as edge. There are significant differences between higher and lower force level with higher I, ω, CW and lower LW at higher force level. Advanced efficiency of information processing in the regional and global perspective indicated dynamical alterations when human faces the higher force tracking task. It suggested that ω may be an important characteristic to classify different force control states with the average classification accuracy of 82.21%. These findings reveal related alterations of functional interactions between muscles involved in precision pinch. The novel method for constructing multiplex muscle network may provide insights into muscle synergies during precision pinch force control.