Construction of microstructure and nutrient transport properties of tibial segmental implant prosthesis

Abstract

Segmental tibial bone defects caused by bone tumors, open fractures, and non-union of large bone segments are one of the challenges in orthopedic diseases. In existing research on load-bearing implants, it has been found that stress mismatch at the bone/implant interface leading to implant loosening and biological instability due to limited depth of bone ingrowth are key obstacles to the development of tibial implants. Therefore,In this study, the mechanical properties and internal fluid properties of three existing bone scaffold microstructures were investigated by finite element analysis.Based on the requirements of tibial segmental bone defect scaffolds, a composite scaffold with a GDP pore structure is prepared. The stress transmission mechanism of its microstructure model and the influence of internal scaffold microstructure on the transport of nutrients are studied. The newly proposed GDP pore structure is suitable for segmental bone defects similar to the tibial diaphysis.