Construction of gastroretentive aminated chitosan coated (sunflower oil /alginate / i-carrageenan) floatable polymeric beads for prolonged release of Amoxicillin trihydrate

Abstract

New gastroretentive floatable polymeric beads were developed for efficient encapsulation and prolonged release of amoxicillin trihydrate (AMT). Herein, sunflower oil (SFO) was entrapped into alginate (Alg)/iota carrageenan (i-CG) doubly networked polymeric beads, and followed by surface-coating with aminated chitosan (AmCs) layer. Diverse analysis tools were employed to investigate the chemical structure, thermal and morphological properties of the formulated [email protected] (SFO/Alg/i-CG) polymeric beads. The formulated polymeric beads exhibited exceptional floating ability exceeded 24 h without floating lag time. Additionally, approximately 93.29% of AMT-drug was successfully encapsulated into the floatable coated polymeric beads. The AMT-drug burst release at pH.1.2 was meaningfully dwindled with increasing AmCs concentration up to 4%., while a prolonged release manner took place up to 25 h. Kinetically, the release mechanism obeyed Peppas-Sahlin model, while the Fickian diffusion was the dominant. The in vitro bio-evaluation assessments revealed that coated polymeric beads possessed excellent mucoadhesion percent reached 93.333%, potent antimicrobial activity and respectable biodegradability under the physiological enzymatic conditions. The cytotoxicity assessment confirmed the safety of the formulated floatable polymeric beads with cell viability reached 96%, suggesting their potential applicability as effectual mucoadhesive carriers for the oral delivery of antibiotics.