Abstract
Nanomaterials (NMs)-based cancer-targeted drug delivery systems have been promoted as a promising therapy. Using silk fibroin (SF), Ru(II)-modified selenium (Ru@Se), Nivolumab (NMB), and heptapeptide (HP), we designed a pH-response innovative Nanomaterials for the drug delivery framework. The constructed NMB@HP/SF-Ru@Se-NMs were nanospheres of ∼100 nm, contributing to enhanced permeability and retention (EPR) in tumor sites. The NMB was released from the pH-dependent nanocarriers, and in an acidic environment, the release of NMB was accelerated. NMB@HP/SF-Ru@Se-NMs demonstrated improved cellular uptake and anticancer efficacy for hepatocellular carcinoma. In addition, the flow cytometry results demonstrated that NMB@HP/SF-Ru@Se-NMs could efficiently destroy cancer cells. Further, histochemical investigations revealed that NMB@HP/SF-Ru@Se-NMs exhibited less toxicity to the primary organs, suggesting that the constructed NMs are biocompatible in vivo. Overall, the findings imply that the nanomaterials-based delivery framework (NMB@HP/SF-Ru@Se-NMs) is a novel treatment for hepatocellular carcinoma.
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