Abstract
The diastereo- and enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand ( 1) was examined. Michael adducts ( 4) were obtained in excellent chemical yields (95∼99%) with high stereoselectivities ( syn- 4 anti- 4 : 16 84 ∼ 1 99 ; ee of anti- 4: 81∼99 %) by the reaction between alkyl phenyl ketones ( 2) and Michael acceptors ( 3) having an alkylidene group.
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