Construction of bionanoparticles based on Angelica polysaccharides for the treatment of stroke

Abstract

Ischemic stroke is an acute and severe neurological disease, resulting in disability and death. The poor drug delivery to cerebral ischemic regions is a key challenge of ischemic stroke treatment. Inspired by the ability of Macrophage membranes to cross the blood-brain barrier, We prepared amphiphilic nanoparticles (AOE@TMP) by linking Angelica polysaccharide (APS) and Ethyl ferulate (EF) using oxalate bond (OL) as the linker arm, with an inner core encapsulated with Tetramethylpyrazine (TMP), and finally using macrophage membrane camouflage (MAOE@TMP). The experimental results show that MAOE@TMP can successfully deliver drugs to the site of brain injury and specifically release it in the microenvironment of the brain injury site, and the three active ingredients in the herb pair could potentiate and significantly reduce the cerebral infarction size.