Abstract
Objective To construct the biomimetie small-diameter artifieial scaffold and deter-mine its biomechanieal properties in vitro in order to compare with the canine carotid artery for next im-plantation. Methods The multilayering scaffold was constructed with polydioxanone (PDS) fibers woven as middle elasticity layer and coved with small intestinal submucosa (SIS) ,and the inner layer was coated with collagen sponge which was mixed with 10% ehondroitin sulfate (CS). Its biomeehanieal properties, such as burst strength, rupture intensity, and compliance, were compared with canine carotid artery. Results The average diameter of constructed scaffolds was 3.83 ram, the burst strength of the scaffold was (43.50±8.30) kPa, the rupture intensity was(19. 10±1.56) N, the strain ratio was (42. 88± 3.16 )% ,and the radial compliance was (5.96±0.87 )%/100 mm Hg. Conclusion The scaffold has a satisfactory biomeehanical properties that meet the mechanical requirements during the implantation in vivo as a tissue engineered blood vessel scaffold. Key words: Tissue engineer; Vascular scaffold; Polydioxanone; Biomeehanies
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