Abstract
Abstract A novel porous Cd(ii) metal–organic framework (MOF) with the chemical composition of {[H3O][Cd(bci)]} n ·2n(H2O) (1, H3bci = bis(2-carboxyethyl)isocyanurate) was prepared via hydrothermal responses of H3bci and Cd(NO3)2·4H2O. Luminescent property investigations indicated that compound 1 had high sensitivity toward Fe3+, and the detection limit of Fe3+ was as low as 2.15 × 10−4 M. The application values of Fe3+ on Hepatitis B were assessed, and its associated mechanism was identified simultaneously. First, the cytotoxic mediator (TNF-α) substance released into plasma was measured through the ELISA. In addition, real-time RT-PCR was employed to determine the Hepatitis B viral replication gene relative expression levels. Finally, the novel compound’s toxicity against human normal liver cells was tested by using the CCK-8 assay.
Highlights
Hepatitis B infection can cause acute and chronic Hepatitis B, thereby resulting in chronic liver diseases, for instance, hepatocellular carcinoma and cirrhosis [1]
The antiviral treatment of interferon and nucleoside analogs has a certain effect in some Hepatitis B
In protecting human safety and ecological balance, developing a new metal–organic framework (MOF)-based luminescent probe with high selectivity together with high sensitivity is essential for determining these harmful substances
Summary
Hepatitis B infection can cause acute and chronic Hepatitis B, thereby resulting in chronic liver diseases, for instance, hepatocellular carcinoma and cirrhosis [1]. At present, establishing the luminescent MOFs for selectively determining the organic small molecules, heavy metal ions, and aromatic explosives has received particular interest [8,9,10,11]. With the development of the modern industry, many harmful substances, including nitroaromatic explosives, volatile organic solvent molecules, and heavy metal ions, have been discharged directly into the environment, which would lead to the sequence of harm to ecological environment and the health of human [18]. In protecting human safety and ecological balance, developing a new MOF-based luminescent probe with high selectivity together with high sensitivity is essential for determining these harmful substances. The luminescence studies demonstrated that the 1 could be employed as a luminescent probe for the high sensitivity Fe3+ ion, and the detection limit of Fe3+ was calculated to be as low as 2.15 × 10−4 M. The compound’s treatment activity against Hepatitis B was investigated, and in meantime, the corresponding mechanism was studied
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
