Construction of a Cerebral Hemorrhage Test System Operated in Real-time

Gen Li,Jian Sun,Hua Feng,Ke Ma,Xiaolin Zheng,Gui Jin,Wei Zhuang,Mingxin Qin,Xu Ning,Qingguang Yan,Shiyuwei Huang

doi:10.1038/srep42842

Abstract

The real-time monitoring and evaluation of the severity and progression of cerebral hemorrhage is essential to its intensive care and its successful emergency treatment. Based on magnetic induction phase shift technology combined with a PCI data acquisition system and LabVIEW software, this study established a real-time monitoring system for cerebral hemorrhage. To test and evaluate the performance of the system, the authors performed resolution conductivity experiments, salted water simulation experiments and cerebral hemorrhage experiments in rabbits and found that when the conductivity difference was 0.73 S/m, the phase difference was 13.196°. The phase difference change value was positively proportional to the volume of saline water, and the conductivity value was positively related to the phase difference of liquid under the same volume conditions. After injecting 3 mL blood into six rabbits, the average change in the blood phase difference was −2.03783 ± 0.22505°, and it was positively proportional to the volume of blood, which was consistent with the theoretical results. The results show that the system can monitor the progressive development of cerebral hemorrhage in real-time and has the advantages of low cost, small size, high phase accuracy, and good clinical application potentiality.

Highlights

Cerebral hemorrhage (CH), which is the most lethal danger to human health, refers to the primary brain parenchymal internal hemorrhage
A plastic container is fixed on a polyester foam cube (10 cm × 8 cm × 5 cm) at the center between the excitation coil and the detection coil, and each container is filled with 10 mL of one of four differently conductive liquids[16,17]: simulated edema fluid, simulated cerebral hemorrhage solution, physiological saline and high-concentration saline (5%)
The results suggested that in the animal model experiment, the whole intracranial electrical conductivity was decreased with increased blood injection volume; the Magnetic inductive phase shift (MIPS) value should decrease monotonically

Summary

Introduction

Cerebral hemorrhage (CH), which is the most lethal danger to human health, refers to the primary brain parenchymal internal hemorrhage. Magnetic inductive phase shift (MIPS) is a new technique for the detection of lesions in brain tissues (e.g., brain edema), CH, and cerebral ischemia[8,9,10]. MIPS is a noncontact method and overcomes the effects of the electrode-skin contact impedance and the high resistivity of the skull that are challenges faced by EIT. The progress of CH will change the electromagnetic properties in the brain, and it can be real-time monitored by the continuous measurement of changes in the MIPS between the induction signal and detection signal. A self-made coil module and a PCI data collection system were combined with LabVIEW to build a real-time CH detection system The performance of this system was tested and assessed via a conductivity resolution experiment, salt water simulation experiment, and animal experiment

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