Abstract
A magnetic nanocarrier was successfully prepared with Fe3O4 magnetic nanoparticles (MNPs), turkey tail polysaccharide and folic acid and then catechin was loaded on this carrier. Radical scavenging activity of catechin loaded MNPs was evaluated via DPPH method (IC50: 1.41 mg/mL). Synthesized Fe3O4 MNPs is hemocompatible with negligible hemolytic effects. The results of cytotoxic effects of synthesized MNPs toward normal fibroblast cells clearly demonstrate that the catechin loaded MNPs were safe and biocompatible. Furthermore, the anticancer activity on MCF-7 cancer cells was indicated by MTT test. The results demonstrated that prepared MNPs have the cytotoxic effects toward MCF-7 comparison with normal fibroblast cell lines.
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