Construction and properties of fluorescence imaging and targeted delivery of UIO-66-NH2 based light-responsive CO releasing material

Abstract

Carbon monoxide (CO) has been studied on the treatment of numerous diseases such as cancers, rheumatoid arthritis, and so on. However, real-time tracking and controlled release of CO gas for a safe and efficient therapy are till a challenging task. Although many CO-releasing molecules (CORMs) have been widely developed and used because of the release of CO by external stimuli, CORMs still have some disadvantages, such as fast CO release, potential toxicity and poor solubility. Herein, light-triggered CO-releasing hybrid material (UIO-66-NH2/CORM@FA-CS-5-FAM) based on UIO-66-NH2 nanoparticles and [Mn(CO)3(CH3CN)(HPYDC)]·CH3CN (H2PYDC = 2, 5-pyridinedicarboxylic acid, abbreviated as CORM) coated with FA-CS-5-FAM was constructed. The composition characteristics of the hybrid material include: a chitosan (CS) increases the residence time of drugs on the application/absorption sites, folic acid (FA) targets the cancer cells and 5-carboxyfluorescein (5-FAM) is used as an imaging agent. Comparison with the free CORM, UIO-66-NH2/CORM@FA-CS-5-FAM nanocomposite exhibits a long-time CO release and possesses the excellent characteristics of targeted cancer cells and fluorescence imaging. Cell viability assays indicate that UIO-66-NH2/CORM@FA-CS-5-FAM shows good biocompatibility and anticancer activity.