Construction and Functional Properties of Multifunctional Chitosan Hydrogel

Abstract

Hydrogel is a kind of new functional polymer material with application value and economic benefit. It has wide application in biomedical field because of its good biocompatibility and hydrophilicity.In this work, chitosan hydrogel was prepared by free radical graft copolymerization using natural biodegradable polymer chitosan as the carrier, temperature sensitive N-isopropylacrylamide (NIPAm) and pH sensitive 2‑acrylamido-2-methylpropane (AMPS) as monomers. The adsorption and drug release properties of chitosan hydrogel are discussed emphatically.The adsorption performance of chitosan hydrogel on copper ions showed that the temperature and the concentration of copper ions had influence on the adsorption. When the concentration of copper ions was 800 mg/L at 25°C, the equilibrium adsorption capacity was 225.8 mg/g, quasi-second order kinetic equation was suitable for describing the adsorption process. With the methylene blue as the drug model, the controlled release results showed that the temperature and the initial drug dosage had great effect on controlled release performance, and the cumulative release rate of 48 h was about 70%, which could achieve sustained release and controlled release to a certain extent.The experimental results also showed that the chitosan hydrogel can be completely degraded for about 20 days with excellent degradation performance. In conclusion, chitosan hydrogel has broad application prospects in drug controlled release, tissue engineering, environmental engineering and so on.