Abstract
The construction of plasticised PVC matrix-type scopolamine ion- selective membrane electrode and its use in the potentiometric determination of scopolamine in pharmaceutical preparations are described. It is based on the use of tlie ion-associate species, fonned by scopolainine cation and 5-nitrobarbitoric counter ion. The basic electrode peifonnance characteristics are evaluated according to IUPAC I-ecoininendatioiis. It exhibited a linear response for 1x10-2–1x10-5 M of scopolamine solutions with a cationic Nernstian slope over the pH range of 4-7. Common organic and inorganic cations showed negligible interference. Direct potentiometric determination of 1x10-2–1x10-5 M aqueous tubocurarine chloride using this membrane electrode system showed an average recovery of 99.05 with a mean standard deviation of 0.12. This electrode system was successfully applied to the potentiometric determination of scopolamine in some pharmaceutical preparations.
Highlights
The coiistniction of plasticised PVC matrix-type scopolamine ionselective ineinbrane electrode and its use in tlie potentioinetric detenninatioii of scopolainine in pliannaceutical preparations are described
Aqueous tuboctirarine chloride using this ineinbrane electrode systein sliowed ail average recovery of 99.05 witli a inean standard deviation of 0.I. This electrode system was successfillly applied to tlie potentioinetric detenninatioii of scopolainine in some pliannaceutical preparations
A inirt~lreof e q ~ ~ avol lumes of 5x10-.' M scopolainine bu~tylbromide and 5r10-' M potassium chloride was used as internal reference solution in \vIiich AgIAgCI reference electrode is dipped
Summary
The coiistniction of plasticised PVC matrix-type scopolamine ionselective ineinbrane electrode and its use in tlie potentioinetric detenninatioii of scopolainine in pliannaceutical preparations are described. Sensor Preparation: The scopola~nine-5-nitrobarbituratewas prepared by mixing 20 1n1 of I M aqueous scopolamine butyl bromide with 20 in[1] of 1 M ethanolic 5nitrobarbituric acid solution '47'. Electrode Calibration: Aliquots of 10 in[1] of l slo-' - 1x 10"' M scopolainine butyl broinide solution were transferred into 50 in[1] beakers and the PVC scopolamine-5nitrobarbitlrrate ineinbrane electrode in conjilnction with an Orion double-jt~~ictioAigi -AgCl reference electrode (Model 90-02) were immersed in the soliltion.
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