Abstract
Edwardsiella ictaluri is a Gram-negative facultative intracellular pathogen causing enteric septicemia of catfish (ESC), a devastating disease causing millions of dollars production losses and treatment costs. E. ictaluri has variety of distinct mechanisms to survive in the stressful host environment. Type VI Secretion System (T6SS) is involved in survival of intracellular bacteria inside the host immune cells. However, the role of T6SS in E. ictaluri virulence is not known yet. Thus, the purpose of this research was to understand the extent to which T6SS is involved in E. ictaluri virulence. To this aim, we generated an E. ictaluri T6SS mutant (EiΔevpF) and assessed its virulence in channel catfish. The fish trials indicated that EiΔevpF is highly attenuated in channel catfish. Also, vaccination of catfish using the EiΔevpF mutant provided a good protection against wild-type E. ictaluri infection in catfish.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
