Construction and assessment of carboxymethyl Bletilla striata polysaccharide/Polyvinyl alcohol wet-spun fibers load with Polydopamine@Metformin microcapsules

Abstract

The purpose of this work was to prepare multifunctional wet-spun fibers via an environment-friendly approach for drug delivery. Currently, drug-loaded fibers often face the following drawbacks, such as drug leakage and burst release. In this study, the fibers were fabricated based on carboxymethyl Bletilla striata polysaccharide-Polyvinyl alcohol composite spinning solution wrapping Polydopamine @Metformin microcapsule and treated with a simple Cu2+-ethanol coagulation bath, which were characterized and evaluated by surface morphology, physicochemical analysis, mechanical performance, swelling percentage, cell viability, release behavior, photothermal effect, washability, antioxidant and antibacterial properties. The fibers had appropriate mechanical properties own to the dual cross-linking formed by inter-and intramolecular hydrogen bond between carboxyl groups and hydroxyl groups and coordination bond between the carboxyl groups and Cu2+. Most importantly, via the encapsulation of PDA@Metformin microcapsule, the fibers were achieved sustained and controlled drug release, and enhanced the antioxidant function. The composite fibers showed high biocompatibility toward the L929 cell line in vitro assay. Interestingly, with the assistance of Cu2+ and near-infrared radiation, the fibers showed effective inhibition against S. aureus and E. coli, avoiding bacterial drug resistance. Therefore, the intended applications of these multifunctional bioactive fibers are used for drug delivery and as wound dressings in medical textiles.