Abstract
A bifunctional fluorescent probe, A-1, was designed and synthesized for the recognition of Cys and viscosity. In the high-viscosity system, the intramolecular rotation of A-1 is restricted, which activates its near-infrared fluorescence. Simultaneously, the probe specifically detects Cys using acrylate as the recognition site. It possesses advantages such as high sensitivity, low detection limit, large Stokes shift (140 nm), high selectivity, and anti-interference properties. In addition, the probe A-1 can target mitochondria before recognition, and aggregate in lipid droplets after reacting with Cys. Based on the above excellent properties, it has been used to monitor changes in Cys and viscosity levels in living cells. And for the first time, it has revealed fluctuations in Cys and viscosity levels in the apoptosis model induced by Cisplatin. This provides a powerful tool for an in-depth study of related disease mechanisms.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.