Construction and Antibacterial Study of Targeted Peptide Nanodrug Delivery System

Abstract

The discovery of broad-spectrum antibiotics has greatly reduced human mortality due to bacterial infections, but the widespread use of broad-spectrum antibiotics in the past 20 years has led to the emergence of multiple drug resistance (MDR) pathogens, making bacterial infection modern serious problems facing medicine. In addition, the abuse of broad-spectrum antibiotics can also cause diseases such as intestinal flora imbalance, colitis, and candidiasis. Therefore, it is of great significance to develop new targeted antibacterial drugs, which can effectively treat bacterial infections while reducing the generation of drug-resistant bacteria and avoiding the imbalance of microbiota in patients. Based on this, we designed a temperature-responsive nano-drug delivery system containing antimicrobial peptides. The system uses gold nanostars as carriers to couple targeted antimicrobial peptides and loads them into thermosensitive hydrogels. It can form a gel according to the increase in the ambient temperature, and the photothermal effect is stable. In vitro antibacterial experiments show that the system has an excellent killing ability for StaphylococcuS.aureus. The method reported in this article hopes to provide a certain reference value for future nanoparticle antibacterial research.