Constructing Biomimic Catalytic Coating with Controlled Nitric Oxide Release Properties by Immobilizing 3,3-Diselenodipropionic Acid on Plasma Polymerized Allylamine Film

Abstract

Nitric oxide (NO) is a signaling molecule that plays a pivotal role in the diagnosis, treatment, and prevention of life threatening cardiovascular disorders. In this work, a facile method to construct catalytic coating with controlled NO release properties has been developed. The process involves in the first-step the deposition of plasma polymerized allylamine coating to introduce amine groups onto the titanium foils, followed by covalently immobilizing 3,3-diselenodipropionic acid (SeDPA), which is an organoselenium compound mimicking glutathione peroxidase-like catalytic production of NO. The NO release correlated positively with the –Se–Se– content in the functionalized film. After 15 d exposure to an NO donor, the –Se–Se– group was well retained with good biostability and ability of NO generation.