Abstract
Glycan microarray analysis is a high throughput method to screen the interaction between heparin oligosaccharides and target proteins. It is a powerful tool to investigate the binding between carbohydrates and carbohydrate‐binding proteins. Unlike other screening methods, microarray analysis uses a very small amount of target proteins (10 μg) to screen an entire library of Heparan Sulfate (HS) oligosaccharides. Currently we offers the microarray analysis covering up to 52 structurally defined HS oligosaccharides with a size range from pentasaccharides (5‐mer) to octodecasaccharides (18‐mer) representing many different sulfation types that can be found in nature.Support or Funding InformationNational Heart, Lung and Blood Institute, 1R01HL094463‐05National Institute of General Medical Sciences, 1U01GM1022137‐01, 1R41GM123792US FDA: U19FD004994‐01,NIH SBIR HHSN261201500019CSymbolic structures of low molecular heparan sulfate synthesized for microarrayFigure 1Workflow of Printed glycan arrays with fluorescent readout.Figure 2
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