Abstract
The various isoforms of cytochromes P450 (CYP) [1] are the major determinants of the pharmacological and toxicological activity of numerous drugs and many other foreign chemicals present in the human environment [2,3]. A major limitation to the use of hepatocyte cultures in pharmacotoxicological studies is their rapid loss of CYP content [4]. This loss of CYP and associated xenobiotic metabolising activity occurs in hepatocyte cultures prepared from the common species of experimental [5] and farm animals [6] as well as in human hepatocyte culture [7] suggesting similar underlying mechanism(s). Thus while the focus in this chapter is on rat hepatocytes, the commentary on control of CYP gene expression in hepatocytes is likely to be of relevance to liver cell cultures prepared from other species.
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