Constituents of the roots of Melochia chamaedrys

Abstract

The cyclic peptide alkaloid, chamaedrine, was isolated from the roots of Melochia chamaedris (Sterculiaceae), along with four known cyclic peptide alkaloids (adouetine X, frangulaline, scutianine B and scutianine C), and waltherione A, parasorbic acid, propacine, and (−)-epicatequine. Their structures were elucidated on the basis of spectroscopic analysis, especially by 2D NMR ( 1H– 1H-COSY, NOESY, HMQC, HMBC).