Abstract

The tubers of Lepidium meyenii contain the benzylated derivative of 1,2-dihydro- N-hydroxypyridine, named macaridine, together with the benzylated alkamides (macamides), N-benzyl-5-oxo-6 E,8 E-octadecadienamide and N-benzylhexadecanamide, as well as the acyclic keto acid, 5-oxo-6 E,8 E-octadecadienoic acid. The structure elucidation of the isolated compounds was based primarily on 1D and 2D NMR spectroscopic analyses, including 1H– 1H COSY, 1H– 13C HMQC, 1H– 13C HMBC and 1H– 1H NOESY experiments, as well as from 1H– 15N NMR HMBC correlations for macaridine and N-benzylhexadecanamide.

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