Abstract

BackgroundConstipation is a common condition among older people, particularly among people living in nursing homes, and the use of drugs such as opioids is one of many factors that contribute to its high prevalence. The aim of this study was to compare the prevalence of constipation and the use of laxatives between 2007 and 2013, to analyze constipation and laxative use among people who are prescribed opioids, and to identify factors associated with constipation.MethodsIn 2007 and 2013, two surveys were performed in the county of Västerbotten in Northern Sweden, comprising all those living in nursing homes. The Multi-Dimensional Dementia Assessment Scale was used to collect data regarding laxative, opioid and anticholinergic drug use, functioning in activities of daily living (ADL), cognition and symptoms of constipation. A comparison was made between 2820 people from 2007 and 1902 people from 2013.ResultsThe prevalence of symptoms of constipation among people living in nursing homes increased from 36% in 2007 to 40% in 2013. After controlling for age, sex, ADL, cognitive impairment and use of opioid and anticholinergic drugs, this difference was found to be statistically significant. When controlled for demographic changes, there was a statistically significant difference in the regular use of laxatives between the respective years, from 46% in 2007 to 59% in 2013. People prescribed opioids and anticholinergic drugs were at increased risk of constipation, while people with a higher ADL score were at decreased risk. Further, among people prescribed opioids and rated as constipated, 35% in 2007 and 20% in 2013 were not prescribed laxatives for regular use, a difference that was found to be statistically significant.ConclusionsThe prevalence of symptoms of constipation increased between 2007 and 2013. Although there was a decrease between the years, there were still a number of people being prescribed with opioids and rated as constipated who were not treated with laxatives. This study therefore indicates that constipation remains a significant problem among people in nursing homes and also indicates that those prescribed opioids could benefit from an increased awareness of the risk of constipation and treatment, if required.

Highlights

  • Constipation is a common condition among older people, among people living in nursing homes, and the use of drugs such as opioids is one of many factors that contribute to its high prevalence

  • This study found that the prevalence of constipation and the use of laxatives among people living in nursing homes increased between 2007 and 2013

  • People prescribed opioids and anticholinergic drugs were at increased risk of constipation, while people with a higher activities of daily living (ADL) score were at decreased risk

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Summary

Introduction

Constipation is a common condition among older people, among people living in nursing homes, and the use of drugs such as opioids is one of many factors that contribute to its high prevalence. The use of drugs is another clinical factor that impacts bowel function in the elderly [3, 7]. Medications such as urinary antispasmodics, tricyclic antidepressants and some antihistamines increase the risk of constipation because of their anticholinergic properties and the use of opioid analgesics is a risk factor for the development of constipation in the elderly in long-term care [8]. The effects include reduced bowel tone and contractility, which prolong transit time [11]

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