Abstract
In the current study, the prolonged light exposure at night on the
 function of pineal gland, melatonin production, pro-inflammatory response and progress of pregnancy in pregnant rats were
 investigated. A long term (entire gestation stage) of 24 h light exposure not
 only modify the morphologies of pinealocytes by decreasing their nucleus/cytoplasm ratio and mitochondrial
 numbers but also reduce the level of circulating melatonin. The biological
 consequences for this constant light exposure in pregnant rats were the
 elevated the pro-inflammatory response indicated by the increased production of
 IL-6 and finally, the termination of pregnancy compared to their controlled counterparts
 under the normal light/dark cycle. The result showed that the pregnancy was
 terminated at the early stage of embryo development. The report, for the first
 time, established a potential association among the pineal function,
 pro-inflammatory reaction and pregnant progress under the influence of light
 exposure. This observation has a high relevant to the rise in human infertility since humans have overexposed to the light
 at night with the increased light pollution globally.
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