Abstract
IN the course of androgen bioassays performed on a consecutive series of urine specimens from each of several cases, it was noted that the daily excretion of androgens varies considerably from time to time in any one individual. On the other hand, when the androgen excretion was tabulated on a per liter basis (i.e., as concentration) we observed a notable degree of constancy for any one case. This observation differs so greatly from what is generally accepted that we were led to study the relation between androgen excretion and urinary volume more closely. A review of the literature for the last five years revealed no thorough investigation of this problem. In the course of a study of the sex hormone excretion of children, Oesting and Webster (1938) reported that the quantity of androgenic substances excreted in the urine is independent of the urinary volume, a fact in keeping with the generally accepted belief.
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