Abstract
Introduction: Prostate cancer exhibits a complex genetic and heterogeneous histological pattern reflecting its multifactorial phenotype. Mast cells mainly known for their role in allergy and anaphylaxis, now regarded as key factor cell in angiogenesis, tissue remodeling and repair, whereas their importance in tumor pathology as either cancer promoter or inhibitor is still debated. Materials and Methods: Study included 100 cases of prostatic lesions with 74 cases of benign prostatic lesions and 26 cases of adenocarcinoma prostate, received in the form of transurethral resection of prostate chips for histopathological examination. The tissues were routinely processed, the paraffin sections stained by hematoxylin and eosin and 1% toluidine blue. Histological diagnosis was made. Mast cell count was done taking a standard of 10 high power fields(x40) and mean were calculated. Distributions of mast cells were noted in stroma, perivascular, periglandular and intraglandular regions. Results: Mast cell count was significantly higher in benign prostatic hyperplasia with mean of 3.6 per high power field whereas absence or low count was found in adenocarcinoma prostate with mean of 1.7 per high power field. Mast cells were located predominantly in stromal region in both BPH and adenocarcinoma prostate; in rest of the areas the numbers were comparable. Conclusion: In this study we observed significant increase in mast cell count in stroma of BPH compared to adenocarcinoma indicating that mast cell density is inversely proportional to malignancy. This suggests high mast cell count favors the prognosis. Keywords: Mast cells, Benign Prostatic Hyperplasia, Adenocarcinoma.
Highlights
Prostate cancer exhibits a complex genetic and heterogeneous histological pattern reflecting its multifactorial phenotype
Overall mean age of patient presented with benign prostatic hyperplasia was 55 years and prostate adenocarcinoma was 68 years
Mast cell count was significantly higher in fibro muscular stroma in benign prostatic hyperplasia with mean of 3.6 per high power field W ere as absence or low count was found in adenocarcinoma prostate with mean of 1.7 per high power field
Summary
Prostate cancer exhibits a complex genetic and heterogeneous histological pattern reflecting its multifactorial phenotype. Conclusion: In this study we observed significant increase in mast cell count in stroma of BPH compared to adenocarcinoma indicating that mast cell density is inversely proportional to malignancy. This suggests high mast cell count favors the prognosis. 3. Tumors are commonly infiltrated by large number of immune cells which are scattered within tumor and loaded with array of cytokines, chemokines, inflammatory and cytotoxic mediators. Tumors are commonly infiltrated by large number of immune cells which are scattered within tumor and loaded with array of cytokines, chemokines, inflammatory and cytotoxic mediators This complex network reflects the assortment in tumor biology and tumor host interactions. Mast cell interaction with tumor is related to microenvironment which largely determines the phenotype of the tumor. 1
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