Abstract
Purpose: To investigate reported absence of hyperkalema episodes due to high [K+] and the absence of hypersensitivity reactions due to tracer proteins in tender coconut water following IV infusion. To establish tender coconuts as a prospective natural large volume parenteral ‘dosage unit’. Method: Fluid from nuts identified with ‘Rosette Alba’ sign to be of 5-6 months maturity were evaluated. Important tests performed were the shelf life, direct tapping of the fluid, hemolysis and the molecular mass studies of tracer proteins by SDS PAGE gel electrophoresis. Results: Calculations indicate that [K+] dropped by 1/6th -1/9th in blood following IV infusion of fluid. Proteins are in the low molecular mass range of 10,000 Da, hence below potent antigen range. Conclusion: Drastic dilution of [K+] and the presence of hyperkalemia antidotal ingredients in the fluid and the low molecular mass of the proteins found in low concentration of 0.2 % and IV administration bypassing immunogenic subcutaneous route could be the possible reasons for absence of hyperkalemia and hypersensitivity reactions. The study did not show any dosage parameter that adversely restrains IV infusion potential of tender coconut water.
Highlights
Human blood and tender coconut water (TCW) derived naturally from animal and plant sources could be administered intravenously to human beings. This very exclusivity of TCW deserves rigorous researching about its intravenous (IV) infusion potential. It is the liquid endosperm of the fruit, histologically a live liquid tissue as it carries free nuclei undergoing division.[1]. In over 70 years of TCW intravenous use, no untoward reactions have been reported
The present study aims for a scientific investigation of the pharmaceutical attributes of TCW as an IV infusion fluid
Harvesting of the tender coconuts for infusion purpose must be according to all applicable good manufacturing practices (GMP) under the supervision of a trained person
Summary
Human blood and tender coconut water (TCW) derived naturally from animal and plant sources could be administered intravenously to human beings. This very exclusivity of TCW deserves rigorous researching about its intravenous (IV) infusion potential. It is the liquid endosperm of the fruit, histologically a live liquid tissue as it carries free nuclei undergoing division.[1] In over 70 years of TCW intravenous use, no untoward reactions have been reported. The values for [Na+] in TCW rangers from 1.96-2.67 mMols/L (or mEq/L) compared to 134-145 mEq/L in blood. The values for [K+] in TCW is 56.44-87.82 mMols/L (or mEq/L) compared to 3.5-5 mEq/L in blood (Table 1). TCW is free of usual hazards of blood transfusion and had been administered
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