Consistent Fixed-Effects Selection in Ultra-high dimensional Linear Mixed Models with Error-Covariate Endogeneity

Abstract

Recently, applied sciences, including longitudinal and clustered studies in biomedicine require the analysis of ultra-high dimensional linear mixed effects models where we need to select important fixed effect variables from a vast pool of available candidates. However, all existing literature assume that all the available covariates and random effect components are independent of the model error which is often violated (endogeneity) in practice. In this paper, we first investigate this important issue in ultra-high dimensional linear mixed effects models with particular focus on the fixed effects selection. We study the effects of different types of endogeneity on existing regularization methods and prove their inconsistencies. Then, we propose a new profiled focused generalized method of moments (PFGMM) approach to consistently select fixed effects under 'error-covariate' endogeneity, i.e., in the presence of correlation between the model error and covariates. Our proposal is proved to be oracle consistent with probability tending to one and works well under most other type of endogeneity too. Additionally, we also propose and illustrate a few consistent parameter estimators, including those of the variance components, along with variable selection through PFGMM. Empirical simulations and an interesting real data example further support the claimed utility of our proposal.