Abstract
Considering autophagy, β-Catenin and E-Cadherin as innovative therapy aspects in AML.
Highlights
Acute myeloid leukemia (AML) is the most common type of leukemia and characterized by a massive accumulation of immature and non-functional myeloid precursor cells in the blood and the bone marrow
Impressive therapeutic successes have been achieved in acute promyelocytic leukemia (APL) exhibiting striking remission rates and long-term survival up to 90%
The PML-RARα fusion protein represses the transcription of genes, which are important for myeloid differentiation
Summary
Acute myeloid leukemia (AML) is the most common type of leukemia and characterized by a massive accumulation of immature and non-functional myeloid precursor cells in the blood and the bone marrow. The degradation of PML-RARα can be induced by pharmacological doses of all-trans retinoic acid (ATRA), thereby enabling transcription and terminal differentiation of immature precursor cells.[2] ATRA is only clinically successful for the small subset of APL patients.
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