Abstract
Monomethylhydrazine (MMH) and unsymmetrical dimethylhydrazine (UDMH), but not N-methyl-N-formylhydrazine (MFH), a mushroom poison, can be oxidized by the weak oxidant 2,6-dichlorophenolindophenol. Hydrogen peroxide is formed by this oxidation, and has been found to cause decay of DNA in aqueous solution as measured by the decreased viscosity of a DNA solution in the presence of the hydrazines. Furthermore, MMH and UDMH but not MFH inhibit the incorporation of [3H]thymidine and [3H]uridine into DNA and RNA of Ehrlich ascites carcinoma (EAC) cells. These experiments show that MFH is an inactive compound in contrast to MMH and UDMH. Since the hydrolysis rate of MFH, to produce MMH, is low, it is concluded that MFH must be activated in vivo into toxic metabolites which are ultimately responsible for the known high carcinogenicity of MFH.
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