Consideration of Nonuniformity in Elongation of Microstructures in a Mechanically Tunable Microfluidic Device for Size-Based Isolation of Microparticles

Abstract

This paper presents an investigation of the nonlinearity behavior in deformation that appears during the linear stretching of the elastomeric microstructures in a pillar-based microfilter. Determining the impact of the nonuniformity in strain on the geometry and performance of such a planar device under in-plane stretch is the motivation for this study. A semiempirical model is used to explain the physical strain-stress behavior from the root to the tip of the micropillars in the linear arrays in the device. For microfabrication of the device, the main substrate is elastomeric polyurethane methacrylate, which is utilized in an ultraviolet-molding method. Optical imaging and scanning electron microscopy were used to evaluate the deformation of the microstructures under different loading conditions. It was demonstrated that by applying mechanical strains of <;20% (ΔL/L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> ) on the elastomeric device using a modified syringe pump, the spacing of the pillars is increased effectively to about three times the size of the initial setting of 5.5 μm, which corresponds to a strain of above 180% in the absence of nonuniformity effects. This simple yet interesting behavior can be exploited to rapidly adjust a microfluidic device for application to the separation of microbeads or blood cells, which would normally require the geometrical redesign and fabrication of a new device.