Abstract
Introduction. Hops (Humulus lupulus L.) is used as a raw material for the production of beer but has also biological properties. Phytoestrogens present in the hops have an antioxidant, anti-inflammatory and probiotic role, while having an effect on the diseases of osteoporosis, diabetes and vasomotor effects (calf) during menopause. Material and method. 8-prenilnaringenine was prepared according to a modification of the initial method. To a cooled solution of naringenin was added a methanolic sodium methoxide solution and prenyl bromide. Results and discussions. The estrogenic effect has been attributed to substances such as β-acids, β-sitosterol, xanthohumol and desmethylxanthohumol. Further investigations have shown that 8-prenylnaringenine is a major hops estrogen. 8-prenilnaringenin acts on estrogen receptors that mediate bone osteoblastic formation and inhibit osteoclastic bone resorption.
Highlights
Hops (Humulus lupulus L.) is used as a raw material for the production of beer but has biological properties
The estrogenic effect has been attributed to substances such as β-acids, β-sitosterol, xanthohumol and desmethylxanthohumol
Un suport suplimentar a fost oferit de către constatările recente privind activitatea in vivo a 8-PN utilizând un test acut bazat pe capacitatea estrogenilor de a induce o creştere rapidă a permeabilităţii vasculare uterine la şoareci ovariectomizaţi, precum şi de stimulare a mitozelor în uter şi vaginul şoarecilor experimentate prin administrarea de 8-PN în apa de băut [26]
Summary
Hameiul (Humulus lupulus L.) este folosit ca materie primă esenţială pentru fabricarea berii, dar posedă şi o serie de proprietăţi biologice. Fitoestrogenii prezenţi în hamei prezintă un rol antioxidant, antiinflamator şi probiotic, având efect în cazul osteoporozei şi al diabetului, precum şi în diminuarea efectelor vasomotorii (bufeuri) din perioada menopauzei. 8-prenilnaringenina a fost preparată conform unei modificări ale metodei iniţiale. La o soluţie răcită de naringenină s-a adăugat o soluţie metanolică de metoxid de sodiu şi bromură de prenil. Efectul estrogenic a fost atribuit unor substanţe cum ar fi β-acizi, β-sitosterol, xanthohumol şi desmetilxanthohumol. Investigaţiile ulterioare au arătat că 8-prenilnaringenina este un principal estrogen din hamei. 8-prenilnaringenina acţionează asupra receptorilor estrogenici α, ce mediază formarea osteoblastică osoasă şi inhibă resorbţia osoasă osteoclastică. Cuvinte cheie: hamei, fitoestrogen, 8-prenilnaringenina, estrogen, antioxidant, receptor estrogenic
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
