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Abstract
GLP-1 agonists are novel medications. Its relationship with the decrease in gastric motility is clear; this presents a challenge when performing an induction under general anesthesia. Therefore, knowing its pharmacokinetics and the current recommendations described by the American Society Anesthesiologists (ASA) to evaluate perioperative risk during elective surgery are important. The objective is to review pharmacokinetics of GLP-1 analogues and evaluate current recommendations for perioperative management in patients undergoing elective surgery. We searched for articles using the keywords and medical topic titles: incretins; glucagon-like peptide-1; GLP-1; glucagon-like peptide 1 receptor agonists; GLP-1 RA; perioperative period; perioperative; perioperative; stomach emptying; gastric emptying; pulmonary aspiration; aspiration of gastric content; regurgitation of food; and regurgitation. The evidence was analyzed, synthesized and reported narratively. The elimination half-life of GLP-1 agonists determines the suspension time prior to the surgical procedure. Gastric ultrasound is a potentially quantitative tool to evaluate gastric contents prior to elective surgery.
Published Version
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